<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kezar III, H.S.</style></author><author><style face="normal" font="default" size="100%">Hutchison, T.L.</style></author><author><style face="normal" font="default" size="100%">Tyler, P.C.</style></author><author><style face="normal" font="default" size="100%">Morris, P.E. Jr.</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">Carbohydrate Chemistry</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis of deuterated-BCX-1777, a potent inhibitor of purine nucleoside phosphorylase</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Labelled Compounds and Radiopharmaceuticals</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">article</style></keyword><keyword><style  face="normal" font="default" size="100%">Catalysis</style></keyword><keyword><style  face="normal" font="default" size="100%">chemical bond</style></keyword><keyword><style  face="normal" font="default" size="100%">Deuterium</style></keyword><keyword><style  face="normal" font="default" size="100%">drug structure</style></keyword><keyword><style  face="normal" font="default" size="100%">drug synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">immucillin h</style></keyword><keyword><style  face="normal" font="default" size="100%">mass spectrometry</style></keyword><keyword><style  face="normal" font="default" size="100%">purine nucleoside phosphorylase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">unclassified drug</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2002</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.scopus.com/inward/record.url?eid=2-s2.0-0036157739&amp;partnerID=40&amp;md5=e6d060500e35c01106b223f0a196b901</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">45</style></volume><pages><style face="normal" font="default" size="100%">71-78</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BCX-1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme-catalyzed C-N bond cleavage of nucleosides. BCX-1777 is a slow-onset, tight-binding inhibitor with a K1* of 23 pM and is one of the most potent inhibitors known for the enzyme. In support of our BCX-1777 program, a mass spectrometric assay has been developed utilizing 5′-[2H]-BCX-1777 as an internal standard. The synthesis of 5′-[2H]-BCX-1777 is described in this report. Copyright © 2002 John Wiley &amp;amp; Sons, Ltd.</style></abstract></record></records></xml>