<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thompson, O.B.</style></author><author><style face="normal" font="default" size="100%">Andrews, M.K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Measuring Doppler-like power spectra and dermal perfusion using laser speckle contrast with multiple exposures</style></title><secondary-title><style face="normal" font="default" size="100%">Progress in Biomedical Optics and Imaging - Proceedings of SPIE</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Arterial occlusions</style></keyword><keyword><style  face="normal" font="default" size="100%">Autocorrelation</style></keyword><keyword><style  face="normal" font="default" size="100%">Autocorrelation functions</style></keyword><keyword><style  face="normal" font="default" size="100%">Blood flow</style></keyword><keyword><style  face="normal" font="default" size="100%">Brownian motion</style></keyword><keyword><style  face="normal" font="default" size="100%">Brownian movement</style></keyword><keyword><style  face="normal" font="default" size="100%">Classifiers</style></keyword><keyword><style  face="normal" font="default" size="100%">Clinical application</style></keyword><keyword><style  face="normal" font="default" size="100%">Computer simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Doppler</style></keyword><keyword><style  face="normal" font="default" size="100%">Doppler effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Experimental measurements</style></keyword><keyword><style  face="normal" font="default" size="100%">Human tissues</style></keyword><keyword><style  face="normal" font="default" size="100%">Laser doppler</style></keyword><keyword><style  face="normal" font="default" size="100%">Laser Doppler systems</style></keyword><keyword><style  face="normal" font="default" size="100%">Laser speckle</style></keyword><keyword><style  face="normal" font="default" size="100%">Laser speckle contrast</style></keyword><keyword><style  face="normal" font="default" size="100%">Light</style></keyword><keyword><style  face="normal" font="default" size="100%">Light fluctuation</style></keyword><keyword><style  face="normal" font="default" size="100%">Light intensity</style></keyword><keyword><style  face="normal" font="default" size="100%">Multiple exposure</style></keyword><keyword><style  face="normal" font="default" size="100%">Optical systems</style></keyword><keyword><style  face="normal" font="default" size="100%">Perfusion images</style></keyword><keyword><style  face="normal" font="default" size="100%">Power spectrum</style></keyword><keyword><style  face="normal" font="default" size="100%">Power-spectra</style></keyword><keyword><style  face="normal" font="default" size="100%">Regression analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Scanning lasers</style></keyword><keyword><style  face="normal" font="default" size="100%">Speckle</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectral density</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectral information</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.scopus.com/inward/record.url?eid=2-s2.0-77951715934&amp;partnerID=40&amp;md5=db5ab4146049391dd9d19bd70d79dc5d</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">7563</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Laser speckle contrast measurements provide effectively instantaneous maps of dermal perfusion, using easily obtainable hardware, but such maps are qualitative. Clinical applications of these techniques require a good theoretical and experimental foundation of understanding before relating them to a physiologically significant, quantitative perfusion value. We have confirmed that multiple-exposure laser speckle methods produce the same spectral information as laser Doppler measurements when applied to targets such as human tissue with embedded moving scatterers. This confirmation is based on both computer simulation of laser speckle data and experimental measurements on Brownian motion and skin perfusion using a laser Doppler system and a multiple-exposure laser speckle system. The Power Spectral Density (PSD) measurements of the light fluctuations derived using both techniques are equivalent. Dermal perfusion images can therefore be measured in exactly equivalent terms by either laser speckle contrast or more laborious scanning laser Doppler methods. Most analyses relating laser speckle contrast to perfusion depend on assuming a particular temporal autocorrelation function for the light intensity fluctuations in biospeckle. Using multiple-exposure laser speckle allows the autocorrelation function to be measured rather than assumed. Measured autocorrelation functions and their related power spectra for dermal perfusion are presented, including measurements under arterial occlusion to investigate a 'biological zero': the speckle blur relating to the remaining movement of tissue constituents when there is no net blood flow. © 2010 Copyright SPIE - The International Society for Optical Engineering.</style></abstract></record></records></xml>